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Enclomiphene - Overview
Enclomiphene is a medication sometimes prescribed to men who need treatment for low testosterone levels, generally due to secondary hypogonadism. People who might need an enclomiphene prescription can use Push Health to connect with a medical provider who can prescribe the medication when appropriate to do so.
What Is Enclomiphene Used For?
Enclomiphene is sometimes prescribed to men to elevate testosterone levels, particularly in the setting of a condition called secondary hypogonadism. Enclomiphene belongs to a class of medications known as selective estrogen receptor modulator (SERMs). The medication is thought to work by acting as an estrogen receptor antagonist in certain glands. Through this process, it helps increase luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels which stimulates the testes to produce more testosterone and sperm. Enclomiphene is the trans-isomer of clomiphene citrate (Clomid).
Enclomiphene - Dosage and Cost
Enclomiphene is sometimes prescribed as 12.5 mg every other day or daily. Some patients benefit from 25 mg daily. Ultimately, any enclomiphene dosage and regimen used depends on the judgement of the prescribing medical provider.
Enclomiphene typically ranges in price from $60 - $100 / month when paying out of pocket. Most insurance plans will not cover costs associated with the medication but it may be worth checking.
Can I Buy Enclomiphene Online?
Enclomiphene requires a prescription to be dispensed by a pharmacy in the United States. People who might need an enclomiphene prescription can use Push Health to connect with a medical provider who can prescribe the medication when appropriate to do so.
Frequently Asked Questions about Enclomiphene
Is enclomiphene FDA-approved?
No. Enclomiphene is not FDA-approved for any indication as of 2026. Use for secondary hypogonadism is off-label and typically requires compounding.
How is enclomiphene different from clomiphene (Clomid)?
Clomiphene citrate is a racemic mixture of enclomiphene (trans) and zuclomiphene (cis). Enclomiphene is the isomer primarily responsible for raising testosterone. Some men tolerate pure enclomiphene better.
How does enclomiphene compare with testosterone replacement?
Exogenous testosterone raises serum levels but suppresses the body’s own LH/FSH and can reduce or stop sperm production. Enclomiphene stimulates the body’s own production and is more likely to preserve fertility. The ultimate medication choice depends on fertility goals, response, tolerability, and provider judgment.
What monitoring is needed?
Baseline and follow-up labs are sometimes ordered and typically include total (and free) testosterone, LH, FSH, estradiol, hematocrit, and sometimes other tests. A medical provider can determine the appropriate panel.
What are common side effects from enclomiphene?
Side effects include headache, hot flashes, nausea, and mood changes. Some men report changes in libido or energy. Serious side effects appear uncommon in available data.
Who might be a candidate?
Men with confirmed secondary hypogonadism who prefer to raise endogenous testosterone and maintain fertility potential. It is not appropriate for primary testicular failure or for men who simply want testosterone without a medical evaluation.
Can I drink alcohol while taking enclomiphene?
Moderate alcohol use is not strictly prohibited but heavy use can affect hormones and overall health. Discuss alcohol intake with your provider before using the medication.
Enclomiphene - Side Effects
Enclomiphene may cause side effects such as headache, nausea, visual disturbances, lower libido, reduced energy and mood changes. In general, the medication is tolerated reasonably well.
Important other considerations:
- Off-label status means that long-term safety data is more limited than for FDA-approved therapies.
- Enclomiphene may not be appropriate for men with primary hypogonadism (high LH/FSH).
- Baseline evaluation for causes of low testosterone is important.
- Regular lab monitoring is necessary to assess response and safety.
Fertility goal, cardiovascular risk factors, and all medications currently being used should be discussed with a medical provider before starting therapy. People with an allergy to the medication should avoid using it.
How to Get Enclomiphene with Push Health
- Complete a brief health intake. Provide information about symptoms of low testosterone, fertility goals, current medications, and relevant medical history.
- Connect with a licensed medical provider. A medical provider will review your information and determine whether enclomiphene might be appropriate for you.
- Receive your prescription. When appropriate, your medical provider can prescribe enclomiphene (typically to a compounding pharmacy).
- Obtain your medication and follow your plan. Compounded enclomiphene is prepared according to the prescription. Follow any recommended lab schedule and report any side effects promptly.
No health insurance or subscription is required. Medical providers are available now.
More Enclomiphene Information
Last updated September 30, 2026. Given the evolving nature of medicine and science, this information might not be accurate and should not be construed as medical advice or diagnosis / treatment recommendations. Please consult a licensed medical provider if you have additional questions. Please call 911 immediately or go to the nearest emergency room if you believe you are experiencing a medical emergency.