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Zepbound - Overview
Zepbound is a medication sometimes prescribed to people who need medical treatment for weight management. People who might need a Zepbound prescription can use Push Health to connect with a medical provider who can prescribe Zepbound medication when appropriate to do so.
What Is Zepbound Used For?
Zepbound prescription medication is sometimes prescribed to people who need medical treatment for weight management (weight loss) with certain BMI characteristics or people who are overweight in the setting of certain other medication conditions. Zepbound injection medication, like Mounjaro contains the ingredient tirzepatide. Zepbound medication combines a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist - somewhat similar to Ozempic and Wegovy. Zepbound prescription medication is thought to help reduce hunger, improve insulin sensitivity, regulate glucagon levels and assist with controlling blood glucose levels and should be used in conjunction with diet and exercise. Following administration, the median time to maximum plasma concentration of Zepbound's active ingredient is 24 hours. Zepbound injections can be injected subcutaneously in the abdomen, thigh, or upper arm.
Zepbound for Weight Loss
Zepbound medication was approved by the FDA for weight loss in November 2023. The approval was based on results from 2,539 adults who showed weight loss ranging from 34 lb to 48 lb (dose-dependent), compared to 7 lb on placebo. The SURMOUNT-1 study showed that overweight or obese patients who used tirzepatide, the active ingredient in Zepbound prescription injections, demonstrated substantial weight reduction when compared to placebo. Specifically, most patients in the trial were able to have a 5% weight loss while people who received 10 mg or 15 mg doses demonstrated 20% reduction in body weight. While some adverse reactions occurred, they were primarily limited to gastrointestinal events. In the SURPASS-2 trial, the active ingredient in Zepbound medication was found to be superior to semaglutide in regards to the mean change in the glycated hemoglobin level with the added effect of weight reduction. Additional benefits were demonstrated in the SURMOUNT-3 and SURMOUNT-4 trials. Participants in the SURMOUNT-3 trial demonstrated an additional 21.1% mean weight loss for a total mean weight loss of 26.6% from study entry over 84 weeks. Participants in the SURMOUNT-4 trial showed a total mean weight loss of 26.0% over 88 weeks. Eli Lilly also started recruitment for a new trial, SURMOUNT-5, which is a phase 3b study to evaluate the efficacy and safety of the active ingredient of the drug in comparison to semaglutide in certain adults. A study published in Nature Medicine in October 2023 showed that the active ingredient in Zepbound medication resulted in study participants losing an additional 18.4% of body weight compared to a gain in the placebo group over a 72 week period. The active ingredient in Zepbound medication is thought to result in greater fat mass loss than lean mass loss in addition to decreasing calorie intake.
Zepbound - Dosage and Cost
Zepbound prescription medication is sometimes prescribed to be started at Zepbound 2.5 mg injected subcutaneously once weekly. From there, Zepbound might be titrated up by 2.5 mg increments up to a maintenance dose of Zepbound 5 mg, 10 mg or 15 mg once weekly, depending on the specific needs of the patient. Ultimately, the dosage of Zepbound prescription medication used depends on the judgement of the prescribing medical provider. Zepbound injections (pre-filled, single-dose pens) will be available in six doses - Zepbound 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg and 15 mg and is typically present as a clear, colorless to slightly yellow solution. Zepbound prescription medication is expensive when paying out of pocket, listed at $1,059.87. However, Zepbound coupons may be available online and some insurance plans may help cover costs associated with Zepbound prescription medication when buying Zepbound medication at the pharmacy. Eli Lilly may be introducing a Zepbound savings program at some point and a Zepbound prescription discount card may also help with costs associated with Zepbound injections.
Can I Buy Zepbound Online?
Zepbound requires a prescription to be dispensed by a pharmacy in the United States. For this reason, Zepbound OTC is not available and one cannot just buy Zepbound online. The first step to getting a Zepbound prescription is consulting a licensed medical provider. People who might need a Zepbound prescription can use Push Health to connect with a medical provider who can prescribe Zepbound medication (Zepbound subcutaneous injections) when appropriate to do so.
Get Zepbound Near You
Getting Zepbound prescription medication near you can be somewhat challenging as it is not widely available in pharmacies yet. However, it is anticipated that Zepbound injections will be in larger supply in pharmacies by the end of December 2023 with more Zepbound availability in early 2024.
Zepbound - Side Effects
Zepbound prescription medication can cause side effects when used. The most commonly reported adverse effects following Zepbound prescription injection use included nausea, vomiting, diarrhea, abdominal pain, fatigue, reflux, constipation and injection-site reactions. Zepbound medication should not be used by people with certain types of thyroid cancers or Multiple Endocrine Neoplasia syndrome type 2. It is generally recommended that the Zepbound injection site used be rotated with each dose. Given possible side effects, it is important to discuss potential side effects and other concerns with a qualified medical provider prior to using Zepbound medication. Zepbound and alcohol should not be used together. If a dose of Zepbound medication is missed, it is sometimes recommended that a patient administers the next Zepbound dose within 96 hours. People with a hypersensitivity or allergy to Zepbound medication, ingredients in the formulation, or similar medications should not use Zepbound prescription medication.
More Zepbound Information
Last updated December 4, 2023. Given the evolving nature of medicine and science, this information might not be accurate and should not be construed as medical advice or diagnosis / treatment recommendations. Please consult a licensed medical provider if you have additional questions. Please call 911 immediately or go to the nearest emergency room if you believe you are experiencing a medical emergency.