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Mesalamine (Lialda) - Summary
Mesalamine, marketed under the brand name Lialda, is a medication used primarily in managing symptoms associated with ulcerative colitis. People who need a mesalamine prescription can use Push Health to connect with a nearby medical provider who can prescribe generic mesalamine, including Lialda tablets, when appropriate and safe to do so.
Mesalamine - Mechanism of Action
Mesalamine (Lialda) belongs to a class of medications known as anti-inflammatory agents. Also known as 5-aminosalicylic acid or 5-ASA, mesalamine's mechanism of action is not completely clear. Mesalamine is thought to reduce the production of prostaglandins in the colon by blocking an enzyme known as cyclooxygenase, thereby reducing inflammation. Mesalamine may also affect other factors which are involved in modulating genes related to inflammatory proteins. After oral absorption of Lialda, approximately 20% of the mesalamine dose is absorbed and concentrations in the plasma generally peak within 12 hours. Mesalamine is metabolized by the body and the majority of it is excreted in the urine.
Mesalamine - Dosage and Cost
Many providers will prescribe mesalamine 2.4 grams per day split one to three times per day but the ultimate regimen prescribed depends on the judgement of the prescribing medical provider. As Lialda, mesalamine tablets are covered in a polymer film which breaks down at pH levels above 7, thereby providing some resistance to degradation in the stomach. Instead, Lialda tablets are designed to cause mesalamine release in the terminal ileum of the gastrointestinal tract. As Lialda, mesalamine is not cheap, costing approximately $3 per Lialda 1.2 gram tablet. Mesalamine (Lialda) coupons may be available online or through the manufacturer to help reduce some of the cost. Also, some insurance plans may cover any costs associated with a mesalamine prescription but it depends on one's insurance plan and associated benefits.
Can I Buy Mesalamine Online?
Mesalamine is a prescription medication and one cannot just buy mesalamine online in the United States without first discussing the need for a Lialda prescription with a medical provider. Because of this, mesalamine OTC is not an option as pharmacies will not dispense it. People who need a mesalamine prescription can consider using Push Health to connect with a medical provider who can prescribe mesalamine / Lialda tablets when appropriate and clinically indicated to do so.
Mesalamine - Side Effects
Mesalamine can cause side effects in some people, including headache, nausea, dizziness, flatulence and constipation. Withdrawal symptoms can occur after discontinuing mesalamine use. People who have had an allergic reaction to mesalamine or have a known hypersensitivity should not use the medication. Mesalamine and alcohol should not be used together. Prior to using Lialda tablets or other forms, it is important to discuss potential side effects related to mesalamine use with one's medical provider and pharmacist.
More Mesalamine Information
Last updated October 1, 2019. Given the evolving nature of medicine and science, this information might not be accurate and should not be construed as medical advice or diagnosis / treatment recommendations. Please consult a licensed medical provider if you have additional questions.