Vyleesi Prescription Online

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Vyleesi - Overview

Vyleesi (bremelanotide) is a prescription on-demand injectable medication used to treat acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. Women who might benefit from Vyleesi medication can use Push Health to connect with a medical provider who can prescribe Vyleesi when appropriate to do so.

What Is Vyleesi Used For?

Vyleesi medication contains the active ingredient bremelanotide and is sometimes used in treating women with low sexual desire from a condition known as hypoactive sexual desire disorder (HSDD). Vyleesi belongs to a class of drugs known as melanocortin receptor (MCR) agonists and acts in the central nervous system to help improve sexual desire. Additional research is being done on the active ingredient in Vyleesi medication under the investigational code PT-141. Vyleesi is an alternative to oral flibanserin (Addyi) for women who prefer an as-needed option.

Vyleesi - Dosage and Cost

Typically, Vyleesi 1.75 mg is injected subcutaneously into the thigh or abdomen (as needed) approximately 45 minutes before sexual activity. Ultimately, the Vyleesi prescription used depends on the judgement of the prescribing medical provider and the specific health characteristics of the patient. Generally, patients should not use more than one dose in 24 hours or more than 8 doses per month.

Vyleesi is supplied as a single-dose autoinjector. Vyleesi injections are expensive, costing over $700 per Vyleesi 1.75 mg / 0.3mL autoinjector at most pharmacies in the United States. People paying out of pocket may want to look for a Vyleesi coupon online or check with one's insurance plan to see if the Vyleesi injection can be paid for by insurance. Vyleesi medication is available as a 1.75 mg/0.3 mL solution and should generally be stored at or below 25° C away from light.

Can I Buy Vyleesi Online?

Vyleesi requires prescription in the United States and is not available over the counter. People who need a Vyleesi injection prescription, can use Push Health to connect with a medical provider who can prescribe Vyleesi when appropriate to do so.

Frequently Asked Questions about Vyleesi

What is hypoactive sexual desire disorder (HSDD)?

HSDD is a persistent lack of sexual desire that causes significant personal distress or relationship difficulty. “Acquired” means it developed after a period of normal desire; “generalized” means it is not limited to specific situations or partners.

How is Vyleesi different from Addyi?

Addyi (flibanserin) is an oral tablet taken every night at bedtime. Vyleesi is an on-demand injection used only when sexual activity is anticipated. Choice depends on preference for daily vs. as-needed use, tolerability, and medical history.

How soon before sex should I inject Vyleesi?

At least 45 minutes before anticipated sexual activity.

What are the most common side effects?

Nausea (the most frequent), flushing, injection-site reactions, headache, and vomiting. Nausea often improves with subsequent doses for many patients.

Who should not use Vyleesi?

Vyleesi is contraindicated in women with uncontrolled hypertension or known cardiovascular disease. It is not indicated for postmenopausal women or men. Discuss any history of high blood pressure, heart disease, or pigmentary disorders with your provider.

Can Vyleesi cause darkening of the skin?

Yes. Focal hyperpigmentation (especially on the face, gums, or injection sites) can occur and may not fully resolve after stopping the medication. Discontinue and contact your provider if this develops.

How many times can I use Vyleesi in a month?

No more than 8 doses per month, and no more than one dose in any 24-hour period.

Vyleesi - Side Effects

Vyleesi prescription medication can cause side effects when used. Common side effects that may result from Vyleesi injection use include nausea, headache, flushing, vomiting and pain at the injection site. Vyleesi can slow down the movement of food in the gastrointestinal tract. Elevations in blood pressure and hyperpigmentation can occur from Vyleesi injection use. Vyleesi medication can lead to pigmentation from elevations in the expression of melanin. Vyleesi should not be used more frequently than recommended. Vyleesi prescription medication should not be used more than once every 24 hours. Naltrexone should not be used at the same time as Vyleesi. Discuss alcohol use, other medications, and full medical history with your provider before starting Vyleesi. People with a hypersensitivity to the medication should avoid using Vyleesi.

How to Get a Vyleesi Prescription with Push Health

  1. Complete a brief health intake. Answer questions about your symptoms of low sexual desire, current medications, blood pressure history, and any cardiovascular conditions.
  2. Connect with a licensed medical provider. A provider will review your information to confirm whether Vyleesi is appropriate for you. Same-day consultations are available.
  3. Receive your prescription electronically. If approved, your prescription will be sent to the pharmacy of your choice - no office visit required.
  4. Pick up your medication and learn proper use. Review the autoinjector instructions carefully and do not exceed the recommended frequency.

No health insurance or subscription is required. Medical providers are available now.

More Vyleesi Information

Last updated August 16, 2026. Given the evolving nature of medicine and science, this information might not be accurate and should not be construed as medical advice or diagnosis / treatment recommendations. Please consult a licensed medical provider if you have additional questions. Please call 911 immediately or go to the nearest emergency room if you believe you are experiencing a medical emergency.